USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: HSPB1_HUMAN USC-OGP 2-DE database:  HSPB1_HUMAN HSPB1_HUMAN General information about the entry View entry in simple text format Entry name HSPB1_HUMAN Primary accession number P04792 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Heat shock protein beta-1; Short=HspB1; AltName: Full=28 kDa heat shock protein; AltName: Full=Estrogen-regulated 24 kDa protein; AltName: Full=Heat shock 27 kDa protein; Short=HSP 27; AltName: Full=Stress-responsive protein 27; Short=SRP27;. Gene name Name=HSPB1 Synonyms=HSP27, HSP28 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0510: pI=5.24; Mw=26707 SPOT OGP-0512: pI=5.34; Mw=26520 SPOT OGP-0513: pI=5.41; Mw=26520 SPOT OGP-0515: pI=5.83; Mw=26335 SPOT OGP-0541: pI=6.06; Mw=23783 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0776: pI=5.19; Mw=30153 SPOT OGP-0792: pI=5.57; Mw=29807 SPOT OGP-0796: pI=5.77; Mw=29597 SPOT OGP-0799: pI=5.81; Mw=28870 SPOT OGP-0804: pI=5.83; Mw=27642 SPOT OGP-0805: pI=5.45; Mw=26963 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1012: pI=5.69; Mw=25920 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1241: pI=4.42; Mw=32219 SPOT OGP-1266: pI=5.84; Mw=28952 SPOT OGP-1267: pI=5.29; Mw=28871 SPOT OGP-1273: pI=5.83; Mw=27756 SPOT OGP-1274: pI=6.07; Mw=27522 SPOT OGP-1275: pI=5.05; Mw=27445 SPOT OGP-1276: pI=5.55; Mw=27445 SPOT OGP-1281: pI=5.13; Mw=26515 SPOT OGP-1283: pI=5.35; Mw=25790 SPOT OGP-1286: pI=6.01; Mw=25688 SPOT OGP-1287: pI=6.52; Mw=25485 SPOT OGP-1290: pI=6.61; Mw=24887 SPOT OGP-1304: pI=6.93; Mw=22446 SPOT OGP-1322: pI=5.67; Mw=18705 Cross-references UniProtKB/Swiss-Prot P04792; HSPB1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name HSPB1_HUMAN Primary accession number P04792 Secondary accession number(s) B2R4N8 Q6FI47 Q96C20 Q96EI7 Q9UC31 Q9UC34 Q9UC35 Q9UC36 Sequence was last modified on  September 26, 2001 (version 2) Annotations were last modified on  March 15, 2017 (version 208) Name and origin of the protein Description RecName: Full=Heat shock protein beta-1; Short=HspB1; AltName: Full=28 kDa heat shock protein; AltName: Full=Estrogen-regulated 24 kDa protein; AltName: Full=Heat shock 27 kDa protein; Short=HSP 27; AltName: Full=Stress-responsive protein 27; Short=SRP27; Gene name Name=HSPB1 Synonyms=HSP27, HSP28 Encoded on Name=HSPB1; Synonyms=HSP27, HSP28 Keywords 3D-structure; Acetylation; Chaperone; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Methylation; Neurodegeneration; Neuropathy; Nucleus; Phosphoprotein; Reference proteome; Stress response. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L39370; AAA62175.1; ALT_FRAME; Genomic_DNA EMBL X54079; CAA38016.1; -; mRNA EMBL Z23090; CAA80636.1; -; mRNA EMBL AB020027; BAB17232.1; -; mRNA EMBL U90906; AAB51056.1; -; mRNA EMBL CR407614; CAG28542.1; -; mRNA EMBL CR536489; CAG38728.1; -; mRNA EMBL BT019888; AAV38691.1; -; mRNA EMBL AK311894; BAG34835.1; -; mRNA EMBL DQ379985; ABC88475.1; -; Genomic_DNA EMBL AC006388; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471220; EAW71803.1; -; Genomic_DNA EMBL BC000510; AAH00510.1; -; mRNA EMBL BC012292; AAH12292.1; -; mRNA EMBL BC012768; AAH12768.1; -; mRNA EMBL BC014920; AAH14920.1; -; mRNA EMBL BC073768; AAH73768.1; -; mRNA EMBL X16477; CAA34498.1; ALT_FRAME; mRNA EMBL S74571; AAB20722.1; ALT_FRAME; mRNA CCDS CCDS5583.1; -; . PIR S12102; HHHU27; . RefSeq NP_001531.1; NM_001540.3; . UniGene Hs.520973; -; . PDB 2N3J; NMR; -; A/B=80-176 PDB 3Q9P; X-ray; 2.00 A; A=90-171 PDB 3Q9Q; X-ray; 2.20 A; A/B=90-171 PDB 4MJH; X-ray; 2.60 A; A/C=84-176 B/D=179-186 PDBsum; 2N3J; -; . PDBsum 3Q9P; -; . PDBsum 3Q9Q; -; . PDBsum 4MJH; -; . ProteinModelPortal P04792; -; . SMR P04792; -; . BioGrid 109547; 400; . DIP DIP-412N; -; . IntAct P04792; 307; . MINT MINT-1368692; -; . STRING 9606.ENSP00000248553; -; . BindingDB P04792; -; . ChEMBL CHEMBL5976; -; . DrugBank DB06094; OGX-427; . iPTMnet P04792; -; . PhosphoSitePlus P04792; -; . SwissPalm P04792; -; . BioMuta HSPB1; -; . DMDM 19855073; -; . DOSAC-COBS-2DPAGE P04792; -; . OGP P04792; -; . REPRODUCTION-2DPAGE IPI00025512; -; . REPRODUCTION-2DPAGE P04792; -; . SWISS-2DPAGE P04792; -; . UCD-2DPAGE P04792; -; . EPD P04792; -; . PaxDb P04792; -; . PeptideAtlas P04792; -; . PRIDE P04792; -; . TopDownProteomics P04792; -; . DNASU 3315; -; . Ensembl ENST00000248553; ENSP00000248553; ENSG00000106211; . GeneID 3315; -; . KEGG hsa:3315; -; . CTD 3315; -; . DisGeNET 3315; -; . GeneCards HSPB1; -; . GeneReviews HSPB1; -; . HGNC HGNC:5246; HSPB1; . HPA CAB004439; -; . HPA CAB047330; -; . HPA CAB047331; -; . HPA CAB047332; -; . HPA HPA000497; -; . MalaCards HSPB1; -; . MIM 602195; gene; . MIM 606595; phenotype; . MIM 608634; phenotype; . neXtProt NX_P04792; -; . OpenTargets ENSG00000106211; -; . Orphanet 99940; Autosomal dominant Charcot-Marie-Tooth disease type 2F; . Orphanet 139525; Distal hereditary motor neuropathy type 2; . PharmGKB PA29511; -; . eggNOG KOG3591; Eukaryota; . eggNOG ENOG410YERS; LUCA; . GeneTree ENSGT00760000119238; -; . HOVERGEN HBG054766; -; . InParanoid P04792; -; . KO K04455; -; . OMA DQSFGMP; -; . OrthoDB EOG091G0USC; -; . PhylomeDB P04792; -; . TreeFam TF105049; -; . Reactome R-HSA-4420097; VEGFA-VEGFR2 Pathway; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . SIGNOR P04792; -; . ChiTaRS HSPB1; human; . GeneWiki Hsp27; -; . GenomeRNAi 3315; -; . PRO PR:P04792; -; . Proteomes UP000005640; Chromosome 7; . Bgee ENSG00000106211; -; . CleanEx HS_HSPB1; -; . ExpressionAtlas P04792; baseline and differential; . Genevisible P04792; HS; . GO GO:1904115; C:axon cytoplasm; IEA:GOC; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005856; C:cytoskeleton; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IEA:Ensembl; . GO GO:0000502; C:proteasome complex; ISS:BHF-UCL; . GO GO:0005819; C:spindle; IEA:UniProtKB-SubCell; . GO GO:0030018; C:Z disc; IEA:Ensembl; . GO GO:0042802; F:identical protein binding; IMP:UniProtKB; . GO GO:0044183; F:protein binding involved in protein folding; IMP:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0005080; F:protein kinase C binding; ISS:BHF-UCL; . GO GO:0008426; F:protein kinase C inhibitor activity; ISS:BHF-UCL; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0043130; F:ubiquitin binding; ISS:BHF-UCL; . GO GO:0099641; P:anterograde axonal protein transport; IMP:UniProtKB; . GO GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IMP:BHF-UCL; . GO GO:0061077; P:chaperone-mediated protein folding; IMP:UniProtKB; . GO GO:0035556; P:intracellular signal transduction; IMP:BHF-UCL; . GO GO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; . GO GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; ISS:BHF-UCL; . GO GO:0006469; P:negative regulation of protein kinase activity; ISS:BHF-UCL; . GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL; . GO GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IMP:BHF-UCL; . GO GO:2001028; P:positive regulation of endothelial cell chemotaxis; IMP:BHF-UCL; . GO GO:0038033; P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; IMP:BHF-UCL; . GO GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:BHF-UCL; . GO GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; ISS:BHF-UCL; . GO GO:0010506; P:regulation of autophagy; NAS:ParkinsonsUK-UCL; . GO GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; ISS:BHF-UCL; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0001932; P:regulation of protein phosphorylation; IMP:UniProtKB; . GO GO:0006446; P:regulation of translational initiation; TAS:ProtInc; . GO GO:0006986; P:response to unfolded protein; NAS:UniProtKB; . GO GO:0009615; P:response to virus; IEP:UniProtKB; . GO GO:0001895; P:retina homeostasis; IEP:UniProtKB; . GO GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; TAS:Reactome; . Gene3D 2.60.40.790; -; 2; . InterPro IPR002068; A-crystallin/Hsp20_dom; . InterPro IPR001436; Alpha-crystallin/HSP; . InterPro IPR031107; HSP20; . InterPro IPR008978; HSP20-like_chaperone; . PANTHER PTHR11527; PTHR11527; 1; . Pfam PF00011; HSP20; 1; . PRINTS PR00299; ACRYSTALLIN; . SUPFAM SSF49764; SSF49764; 1; . PROSITE PS01031; HSP20; 1; .

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